Dynamic Pass Box with HEPA Filtration

What is the Dynamic Pass Box with HEPA Filtration?

A dynamic pass box adds a fan, prefilter and HEPA filter that circulate clean air through the chamber. It is used for transfers across a cleanliness step, for example from an ISO 8 room into ISO 7 or ISO 6.

Overview

The chamber has a top-mounted fan filter unit that recirculates air through a prefilter and H13 or H14 HEPA filter at about 0.3–0.5 m/s, then returns air through floor-level grilles. Door interlocks are electromagnetic or electronic, and a controller shows door status and fan operation. Interior surfaces are 304 stainless steel with coved corners and a perforated floor. Standard sizes are 500 × 500 × 500 mm to 800 × 800 × 800 mm, and power is 220 V at roughly 150–250 W. The chamber achieves a cleanliness level of ISO 5 or better inside when at rest, provided the filter is intact. Differential pressure gauges are often included to monitor filter loading.

How does it work?

A pass box is a stainless steel or powder-coated steel chamber with two doors, one facing each side of the wall. Mechanical, electromagnetic or electronic interlocks ensure that only one door can open at a time, so the two areas are never directly connected. Static versions rely on this interlock alone, with smooth surfaces and coved corners that can be wiped down. Dynamic versions add a fan, prefilter and HEPA filter that flush the chamber with clean air, typically at 0.3–0.5 m/s. Some versions include UV-C lamps at 254 nm to reduce surface microbes, or VHP-compatible seals for decontamination. Viewing windows of tempered glass, indicator lamps and door-status controls help operators. Wall-mounting frames must be sealed to the partition to maintain room pressure cascades.

What are the key features?

• Top-mounted fan filter unit with H13 or H14 HEPA
• Recirculating airflow at 0.3–0.5 m/s
• Electromagnetic or electronic interlock
• Door and fan status controller
• Perforated floor with return grilles
• Differential pressure gauge for filter loading

What are the technical specifications?

A typical dynamic pass box with hepa filtration configuration offers internal size of 500 × 500 × 500 to 800 × 800 × 800 mm, air velocity of 0.3–0.5 m/s, filter grade of H13 or H14 HEPA, chamber cleanliness (at rest) of ISO 5 (Class 100), interlock of Electromagnetic or electronic and chamber material of 304 stainless steel. Values are indicative of the product class; the exact figures for each configuration are confirmed on the quotation and the calibration documents supplied with the instrument.

Which applications is it used for?

The Dynamic Pass Box with HEPA Filtration is used in sterile pharmaceutical production, biologics manufacturing, cell therapy facilities and electronics cleanrooms. Across the wider Pass Boxes class, laboratories also deploy it for pharmaceutical material transfer, sterile manufacturing and hospital pharmacies.

Which standards and certifications apply?

Relevant standards and methods include ISO 14644-1 (cleanroom classification), ISO 14644-4 (design and construction), EU GMP Annex 1 (sterile manufacturing), GB 50073 (cleanroom design code), JG/T 382 and EN 1822 (HEPA and ULPA filters). Certification candidates for this model are CE and ISO 9001 manufacturing; each is to be confirmed for the specific configuration before shipment, and certificates are supplied only where they have been issued.

Install the pass box during wall construction or in a prepared opening, sealing the flange with silicone or gaskets so pressure differentials are maintained. Interlock function and emergency release should be tested at commissioning. Clean chambers before and after each use with compatible disinfectants, avoiding chlorides on stainless steel. UV lamps lose output after about 8000 hours and should be replaced and measured with a UV meter. Dynamic boxes require prefilter replacement every 3–6 months and HEPA integrity testing annually. Define SOPs for which items may be transferred and how long doors may remain open, and document cleaning for GMP audits.

How do I select the right Dynamic Pass Box with HEPA Filtration?

Choose the dynamic type when transferring across ISO classes or into an area with a strict contamination control strategy. It costs more and needs maintenance of filters. RFQ: internal size, filter grade, fan speed, interlock logic and alarms.

How does it compare with other Pass Boxes variants?

Decide first whether a static, dynamic or decontamination-capable box is needed. Static boxes suit transfers between rooms of similar class, while dynamic boxes suit a step of at least one ISO class, for example ISO 8 to ISO 7. Check chamber size against the largest item, with common clear sizes from 400 × 400 × 400 mm to 800 × 800 × 800 mm, and the wall thickness, which is 50–100 mm for panels. Select the interlock type, mechanical for cost, electromagnetic or electronic for control and alarms. Consider UV, VHP or bio-decontamination requirements, housing material, and whether the chamber needs a floor-standing roller conveyor. Confirm the electrical and control interface.