Robotic Weighing and Dilution System

What is the Robotic Weighing and Dilution System?

A robotic weighing and dilution system weighs solid or liquid samples and dilutes them to a target concentration automatically. It is used where gravimetric accuracy and traceability are essential in regulated environments.

Overview

The system combines an analytical balance with readability of 0.01–0.1 mg, a robotic arm that moves sample vessels, and liquid handling to add solvent to a target weight or volume. It can record the exact mass dispensed, calculate the required solvent from the sample mass and the target concentration, and log every step. Vessel types include vials, flasks and tubes, and weighing is protected from vibration and draughts by an enclosure. Static control and anti-vibration mounting matter at milligram levels. The software links mass, volume and concentration, supports barcode identification and can export results to a LIMS. The system suits standard and sample preparation in pharmaceutical QC, reference standard handling and any workflow where the exact mass must be documented.

How does it work?

An automated sample preparation system performs the steps that normally precede analysis, using robotic motion, precise liquid handling and sensors under software control. A robotic arm or a moving bed picks a sample container, identifies it by barcode, and presents it to modules that weigh, add solvent, mix, heat, centrifuge, filter or extract. Liquid volumes are measured by syringe pump or positive displacement and verified by gravimetric checks, while temperature, time and agitation are controlled by the method. Solid-phase extraction modules condition cartridges, load sample, wash and elute under controlled flow. Digestion modules add acid and apply a heating program. Each step is recorded for traceability, and error handling detects missing containers, low liquid levels and clogs. The result is a prepared sample or extract delivered to a vial for analysis, with a documented chain of actions.

What are the key features?

• Analytical balance with 0.01–0.1 mg readability
• Robotic vessel handling
• Automatic solvent addition to target
• Mass and concentration calculation
• Enclosure for vibration and draught
• Results export to LIMS

What are the technical specifications?

A typical robotic weighing and dilution system configuration offers type of Robotic weighing and dilution system, balance readability of 0.01–0.1 mg, vessel types of Vials, flasks, tubes, dilution target of By mass or volume, volume range of 10 µL–100 mL and accuracy of ± 0.5 % for solvent. Values are indicative of the product class; the exact figures for each configuration are confirmed on the quotation and the calibration documents supplied with the instrument.

Which applications is it used for?

The Robotic Weighing and Dilution System is used in reference standard preparation, pharmaceutical QC weighing, concentration series preparation and stability sample weighing. Across the wider Automated Sample Preparation class, laboratories also deploy it for sample preparation for elemental analysis, dissolution sample handling and bioanalytical extraction.

Which standards and certifications apply?

Relevant standards and methods include IEC 61010-1 (safety requirements for electrical equipment), ISO 8655 (piston-operated volumetric apparatus), ISO/IEC 17025 (testing and calibration laboratories), USP <1058> (analytical instrument qualification), 21 CFR Part 11 (electronic records and signatures) and ANSI/SLAS microplate standards. Certification candidates for this model are CE and ISO 9001 manufacturing; each is to be confirmed for the specific configuration before shipment, and certificates are supplied only where they have been issued.

Validate the system for the intended methods, covering accuracy, precision, carry-over and robustness, and repeat validation after major changes. Keep an inventory of consumables, calibrants and check standards, and run system suitability checks before critical batches. Clean and calibrate weighing, liquid handling and heating modules on schedule, and verify tip and probe alignment to avoid partial transfers. Control environmental conditions, since temperature and humidity affect small volumes. Back up methods and data, restrict software access by role, and retain audit trails. Train operators on error messages and recovery, and define what the system may do unattended. Review performance data to detect drift before it affects results.

How do I select the right Robotic Weighing and Dilution System?

Choose this system where exact mass and dilution must be recorded automatically. Confirm balance readability, vessel types and static control. RFQ: readability, vessel formats, volumes, target concentrations and LIMS integration. State the required readability and vessel formats.

How does it compare with other Automated Sample Preparation variants?

Define the preparation steps and the range of sample types first, then choose a system that covers them without custom work. Confirm compatibility with your tubes, plates and vials, because format changes force method rewriting. Check volumetric accuracy and precision at the working volumes, and verify that the weighing module meets the readability your method needs. Review heating, mixing and extraction capabilities against the standard methods you follow, and confirm the software supports method editing, audit trails and LIMS import of sample lists and export of results. Consider throughput, walk-away time and the number of samples per run. Ask about validation packages, carry-over testing and service response, since sample preparation errors propagate into every downstream result.